Senior Principal Software Engineer, AI Agents (Dublin, Ireland)

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.    ABOUT ISO Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   Your Impact We are building the largest foundation models in biotech and applying them immediately to cure disease. You will play a pivotal role in ensuring the reliability and scalability of the foundations that make this possible. As a Principal Engineer, you will lead the efforts to harden our systems, ensuring our groundbreaking AI is built on an unshakeable base, working closely with the research team and the Applied ML teams to ensure the infrastructure is stable, reliable and can operate with more data and larger models as we grow.  What You Will Do * Develop and operate our inference platform, serving fleets of cutting-edge machine learning models to scientific applications. * Design strategy and build roadmaps for maturing the platform. * Architect and optimize our next-generation inference services. You will solve core scaling limits, ensuring high-throughput performance and feature parity across our model serving stack. * Contribute to core technical decisions on tooling and architectural design while partnering with science, product, and operations teams to align infrastructure with biotech R&D cycles. * Deliver high-quality and well-tested user-focused features. Skills and Qualifications Essential: * Proven experience in architecting and managing large-scale AI/ML workloads in a production environment. * Expertise in cloud compute design, specifically within Google Cloud Platform (GCP). * Orchestration: Significant experience deploying and managing complex workloads within Kubernetes (GKE). * Professional familiarity with NVIDIA GPU generations and the intricacies of high-performance compute. * Strong programming skills and a "reliability-first" approach to software development. Nice to Have: * A career history that spans both ML Software Engineering and Infrastructure SRE roles. * Experience leading multi-disciplinary projects and navigating complex stakeholder requirements in a fast-paced environment. * Familiarity with workload scheduling, ML efficiency research, and hardware benchmarking. * Experience with Google TPU generations and specialized ML-driven R&D cycles. CULTURE AND VALUES We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.  Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. CREATING AN EXTRAORDINARY COMPANY We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. HYBRID WORKING It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy. >> Click to view other open roles at Isomorphic Labs

Our everyday digital experiences are in the midst of a realtime revolution. Whether chatting alongside a livestreaming event, receiving realtime financial information, or working with colleagues in an online collaborative environment - consumers simply expect realtime digital experiences as standard. At Ably we’re not just witnessing this revolution, we’re powering it - at scale. At the heart of our mission lies a commitment to putting developers first. Ably provides a suite of products to build, extend, and deliver powerful digital experiences in realtime, delivering billions of messages for millions of devices every day and supporting organizations like Harness, EA, Panasonic and HubSpot. Working at Ably means helping to build the infrastructure and technology that will power and shape the future of the internet. The opportunity in front of us is immense. And we’d like your help. ABOUT THIS ROLE As the Technical Lead for Developer Experience at Ably you will report directly to our CTO and co-own the DevEx vision and strategy, transforming our dashboard, documentation platform, and control plane into a world-class experience. You are a senior, hands-on engineer who’s passionate about building for developers like yourself; someone who’ll obsess over the developer journey and elevate the user experience of the Ably platform. You’ll blend deep full-stack expertise with a strong product mindset and lead a team of five engineers where the feedback loop is immediate, because you and your team are the target users of the very ecosystem you are building. DAY TO DAY YOU WILL * Obsess over developer experience. You’ll have broad responsibility for elevating how developers interact with Ably’s platform and services, partnering with the DevEx PM as a unified leadership team to deliver a developer experience that becomes a reference point for the industry. * Lead technical execution and vision. You’ll lead a team of five engineers building customer-facing web applications and own the technical architecture and design decisions for our dashboard, docs platform, marketing website, and billing UI. * Drive a product-first engineering culture. You’ll foster an environment where engineers are themselves principal stakeholders of product features, and obsess over customer outcomes. You’ll challenge the "feature factory" mentality and build a team that takes true ownership of the product. * Thrive in a rapid iteration environment. You’ll operate in a high-velocity workspace where PMs, customers, and engineers co-create features. You’ll lead the team in working full-stack to iterate, improve, and ship improvements quickly. * Champion AI-assisted development. You’ll be a catalyst for AI adoption across the team. You’ll leverage LLMs and AI tools to accelerate velocity without compromising on engineering integrity. * Guide engineering outcomes and quality. You’ll set and enforce high standards for code review, testing, and production readiness. You will participate in incident response and coordinate with the Infrastructure team on platform dependencies and deployments. * Mentor and grow the team. You’ll manage performance, career development, and hiring. You will hold the team accountable for delivery commitments while providing the mentorship needed to turn engineers into product-minded leaders. WE'D LOVE TO TALK IF YOU HAVE * A natural empathy for developer customers because you are the target audience. You are genuinely excited about building developer tools and instinctively understand what good looks like. You're fluent in API design, documentation, and the nuances that differentiate a great developer journey. * Extensive experience leading teams at B2B SaaS or API-first companies. You have a track record of building product-minded engineering cultures where teams take initiative and ownership of product outcomes. * A strong software engineering background with expertise in React, TypeScript, and modern JavaScript, alongside backend experience in Ruby on Rails or Node.js. You're comfortable writing code and building prototypes using our APIs, and have built and shipped customer-facing web applications at scale. * An AI-first mindset. You champion the use of  LLMs and AI tools as productivity multipliers for the team. You see AI as an enabler for higher velocity and output, not a replacement for engineering judgment. * Experience at a startup or growth-stage company or adaptability to thrive in a fast-paced, agile environment with a focus on rapid iteration. To be effective in this role you’ll need excellent communication and cross-functional collaboration skills. BONUS POINTS IF YOU HAVE * Experience delivering solutions used by software developers (developer tooling or APIs) or similar technical personas. * An understanding of pub/sub and familiarity with distributed systems and event based architectures. WHAT’S IT LIKE TO WORK AT ABLY? We’re tackling planet-scale problems and our ambitions are a testament to that. You’ll join a successful, deeply motivated and collaborative team that thrives on innovation, experimentation and autonomy. To get a sense of life at Ably, visit our careers page. You can also read about the origins of Ably's core values on our blog. We believe in fostering a culture that's built on inclusivity and mutual respect among all team members, and we recognise that each individual is different and will want to be supported in their role in different ways. We provide a range of perks and benefits to aid folks' development and wellbeing, allowing them to be their best selves and do great work. * A remote-first and flexible work environment. UK-based teams come together in person once per month in our London hub (next to Old Street) and we get together as a company twice per year. Aside from that, you’re welcome to work wherever suits best for you. * Equity. We’re a growing start-up and we want all team to members to share in the success of the company through our EMI share options programme. * Enhanced holiday allowance. Our policy provides Ablyans with 28 days of paid annual leave (27 regular days, plus a day off to enjoy your birthday). * Enhanced parental leave package, so that you can take the time you need to get to know your new family member, rest and recover. * Home workstation budget of £500 on joining (and £150 p/a thereafter), so that your home office is set up to serve you well and that you have everything you need to work comfortably. * Personal learning and development budget of £1000 annually, and 5% L&D time during working hours to focus on improving your skillset. * Private healthcare with BUPA. * Medical cash plan to cover a range medical and dental costs. * Mental wellbeing coaching and counselling from Self Space. * Monthly wellbeing budget via Juno. * Life assurance and income protection. * Access to Tech & Cycle to Work schemes. * Weekly snack allowance for our end-of-week “Need To Know” meeting. * A fully-paid one-month sabbatical after five years with Ably. DIVERSITY, INCLUSION & BELONGING AT ABLY We believe our differences as individuals is what makes us great. Our people are at the heart of what we do, and we encourage everyone to be their most authentic self at Ably: we see inclusivity and openness as fundamental to creating long-term success as an organization. We encourage applications from all backgrounds regardless of age, disability, gender, sexual orientation, parental status, race, religion, educational background or neurodiversity. Ably has an amazing opportunity ahead of us, and we want anyone to be able to contribute to that opportunity. If you enjoy working as part of a technology company, value open source, and love solving hard problems - then we’d love to hear from you, regardless of whether you fit the job description exactly or not. If in doubt, drop us an email; we’d be more than happy to give you some advice on your application.