Senior Manager, Clinical Scientist

Located at Miami Valley Hospital Free-Standing Emergency Departments (Dayton, OH) Full-Time Day Shift (Exempt/Salaried) Position Summary: Responsible for overall operations of their respective hospital laboratory. The Senior Manager is responsible for the implementation of the strategic plan and budget to ensure the high-quality testing services necessary to achieve the business and patient care objectives of CompuNet Clinical Laboratories. Responsibilities: * Responsible for overall operations of their respective hospital laboratory. The Senior Manager is responsible for the implementation of the strategic plan and budget to ensure the high-quality testing services necessary to achieve the business and patient care objectives of CompuNet Clinical Laboratories. * Responsibilities: * Lead hospital technical and lab support teams to meet business goals, customer expectations, and CompuNet mission/values. * Set operating systems, test schedules, work schedules, and staffing with the Senior Director. * Manage departmental budgets and balance marketing and operational needs. * Coordinate quality assurance and improvement activities. * Serve as operations liaison between the lab and hospital. * Develop technical operations policies with Medical/Technical Directors to meet CLIA ’88, CAP, and regulatory requirements. * Maintain CAP readiness and participate in inspections. * Oversee method verification for new assays and ongoing validation. * Review test menus/methodologies and recommend improvements. * Ensure adequate supply inventory. * Support other departments with method verification, instrument selection, interfacing, correlations, and reference ranges per CLIA ’88. * Manage Engagement Survey results and involve staff in action planning. * Communicate consistently through meetings, scorecards, memos, CE, and follow‑ups. * Select, evaluate, train, and develop staff; ensure complete training and competency documentation. * Provide supervision, mentoring, and fair corrective action. * Complete required company documents on time (timecards, reviews, checklists, RCAs, LMS training). * Contribute to organizational management through sales collaboration, projects, and cross‑functional work. * Prepare monthly quality, productivity, project, and financial reports; submit variance reports. * Oversee compliance activities and assist with compliance policy development. * Provide technical/lab support consultation to clients. * Maintain and update procedure manuals per document control. * Participate in teaching students, residents, and fellows. * Support and promote departmental safety programs and compliance with safety policies. * Maintain professional external contacts. * Promote process improvement and continuous improvement. * Perform additional technical, administrative, or educational duties as needed. Qualifications: * Board‑certified (ASCP) Clinical Laboratory Scientist with a bachelor’s degree and three years of laboratory experience. * Demonstrated success in roles with progressively increasing responsibility, supported by strong skills and abilities. * Integrity and accuracy in decision‑making and independent judgment. * Excellent communication and team‑building skills. * Ability to meet deadlines, manage timetables, and maintain multiple areas of responsibility simultaneously. * Demonstrates the core values of the organization. Physical & Safety Demands: * Visual acuity and hand–finger dexterity to work at a computer for extended periods. * Demonstrates complete integrity and accuracy in test performance and results reporting. * Ability to comprehend verbal and written directions. * Ability to handle stressful situations in a calm manner. * Will have exposure to biohazardous substances and hazardous chemicals. * Familiarity with and adherence to the company’s safety, ergonomic, and health policies. * Compliance with all PPE requirements when in the laboratory or other biohazard areas. * Completion of required safety training and health evaluations in a timely manner. * Ability to anticipate safety hazards, act on unsafe situations, and promote safety awareness.

Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer. Position Summary:  Reporting to the Executive Director, Process Development and Manufacturing, the Senior Manager or Associate Director, Process Development and Manufacturing is a hands-on technical contributor responsible for designing and executing experiments that support process development and for coordinating and providing technical oversight of contract development and manufacturing organizations (CDMOs). This role supports small-molecule programs from research through clinical development and preparation for commercial production. The Senior Manager or Associate Director may serve as the drug substance lead for one or more programs and works independently and collaboratively to plan, execute, interpret, and communicate process development and manufacturing activities across internal and external teams Essential Duties and Responsibilities: * Independently design, execute, and interpret laboratory experiments to develop robust and scalable chemical synthesis processes for starting materials, intermediates, and APIs * Plan and execute phase-appropriate process R&D activities, including reaction optimization, workup, isolation, crystallization, impurity control, and scale-up * Prepare experimental plans, protocols, technical reports, process descriptions, and data summaries that support project decisions and knowledge transfer * Support technical transfer of starting material, intermediate, and API processes to CDMOs and between external manufacturing sites * Collaborate closely with medicinal chemistry, analytical development, drug product, quality, regulatory, and project management colleagues * Serve as drug substance lead or technical representative for assigned programs, coordinating deliverables, timelines, risks, and technical decisions with guidance from senior leadership as appropriate * Provide day-to-day technical oversight of CDMO development and manufacturing activities, including review of protocols, batch records, data, deviations, investigations, and reports * Conduct impurity fate and purge studies, evaluate potentially mutagenic impurities, and contribute to phase-appropriate drug substance control strategies * Apply Design of Experiments (DOE), Quality by Design (QbD), risk assessment, and statistical approaches to build process understanding and define operating ranges * Support process characterization, proven acceptable range studies, pre-validation, process performance qualification, and validation activities for drug substance manufacturing, as appropriate to program stage * Review proposals and scopes of work from CDMOs and CROs and contribute to technical due diligence, vendor selection, and budget planning * Author and review relevant CMC sections and supporting documentation for U.S. and ex-U.S. regulatory submissions * Share technical expertise with colleagues and may provide project-level guidance or mentorship to junior scientists; direct people management is not a primary responsibility * Travel up to 25% for CDMO oversight, technology transfer, manufacturing support, and other critical project activities * Perform all duties in alignment with the Erasca’s core values, policies, and applicable regulations Required Education, Experience and Attributes: * PhD in organic chemistry or a related field with typically 7+ years of relevant industry experience, or MS with typically 10+ years of relevant industry experience, in synthetic organic chemistry and small-molecule drug development * Strong hands-on experience in synthetic organic chemistry and small-molecule process development, including laboratory execution, data interpretation, and troubleshooting * Experience developing and scaling chemical processes at CDMOs or supporting external manufacturing activities * Experience in chemical development involving synthesis, isolation, and crystallization of chiral molecules preferred * Working knowledge of solid-form development, including polymorph screening, crystallization optimization, and related analytical techniques * Strong knowledge of cGMP and relevant ICH guidelines and an understanding of phase-appropriate drug substance development and control strategies * Experience applying Design of Experiments (DOE), Quality by Design (QbD), and risk-based process development principles * Ability to independently manage technical workstreams, prioritize multiple activities, identify risks, and deliver high-quality work in a fast-paced environment * Ability to build effective working relationships with colleagues and external partners across diverse backgrounds and areas of expertise * Excellent written and verbal communication skills, with the ability to clearly present technical data, conclusions, risks, and recommendations * Collaborative, solutions-oriented, intellectually curious, and willing to contribute as an individual contributor wherever needed * Strong learning orientation, curiosity, and commitment to science and patients   The anticipated salary range for this position is $180,000 to $215,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etcetera. In addition to base salary, the hired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price.    Along with our casual, collaborative, and fun work and the chance to make your mark in our mission to erase cancer, Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off, Holiday, and Sick Leave, Medical, Dental and Vision Plans, Short- and Long-Term Disability, Basic and Voluntary Life/AD&D Coverage, Flexible Spending Accounts (FSA, HSA, and Commute), Critical Illness and Accident Coverage, Pet Insurance, Employee Assistance Program, 401(k) Plan with Erasca contribution, and the opportunity to participate in an Employee Stock Purchase Program.  Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.